CURRICULUM VITAE

February 15, 2006

CURRICULUM VITAE

Tony Jer-Fu Lee, Ph.D. College of life Sciences Tzu Chi University,

Hualien, Taiwan

Taipei Medical College, Taipei, Taiwan, 1963-1967

B.S. Pharmacy

West Virginia University School of Medicine, Morgantown, W. Va., 1969-1973

Ph.D. Pharmacology

UCLA School of Medicine, Los Angeles, California, 1973-1975

Postdoctoral fellow, Pharmacology

Professor and Dean, College of Life Sciences, Tzu Chi University, Hualien, Taiwan, 2002-

Professor, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, July, 1987-2002

Associate Professor, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, July, 1980-June, 1987.

Assistant Professor, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, October, 1975-July, 1980.

Visiting Professor, Sun Yat-Sen University of Medical Sciences, Guangzhou, Guangdong, China, 1987-1992

Visiting Professor, Science University of Tokyo, Japan, 1990

Adjunct Professor, Taipei Medical College, Taipei, Taiwan, 1996

Visiting Professor, Tri-service General Hospital/National Defense Medical Center, Taipei, Taiwan, 1999

Visiting Professor, Okayama University, Japan, 2003

: Cardiovascular and autonomic pharmacology

1. Teaching assistant; Dept. of Pharmacology, West Virginia University, (1969-1973)

2. Guest Lecturer on Autonomic Pharmacology, USC, California, 1974.

3. Lecturer in advanced physiology and pharmacology of autonomic nervous and

cardiovascular system, Southern Illinois University School of Medicine (1977-2002).

4. Development and delivery of Medical Pharmacology, SIU-Springfield, (1975-2002).

Course Coordinator - Advanced Cardiovascular Pharmacology for graduate students, SIU (1981-2002)

6. Course Coordinator - Cardiovascular pharmacology for medical students, SIU (1981-2002)

7. Course Coordinator - Ophthalmic Drugs for medical students, SIU (1976-2002)

8. Course Coordinator - Methods in Pharmacology for graduate students, SIU (1981-2001)

9. Lecturers in Advanced Neuropharmacology for graduate students, SIU (1981-2002)

10. Director, Sophomore Medical Pharmacology, SIU, 1993-1994; 1999-2000

11. Director, Graduate Program in Department of Pharmacology, SIU, 1996-1997

12. PBLC (problem-based learning curriculum), Pharmacology director 1998-1999

13. Basic science Director for PBLC circulation segment (cardiovascular/renal/respiratory) for

sophomore medical students; 1999-2002

1. Professional Society Memberships:

a. American Society for Pharmacology and Experimental Therapeutics

b. American Association for the Advancement of Science

c. Midwest Society of Electron Microscopist, Inc.

d. Electron Microscopy Society of America

e. Society for Neuroscience

f. American Heart Association Stroke Council

g. American Heart Association High Blood Pressure Research Council

h. Member, Goals and Planning Committee, International Society for Cerebral

Blood Flow and Metabolism, Inc. 1999-2000

i. Member, Program Committee, International Society for Cerebral Blood Flow

and Metabolism, Inc. 1999-2000

j. North American Vascular Biology Organization (NAVBO)

k. Taiwanese Pharmacology society

l. Neuroscience Society (Taiwan)

2. Administrative Services/Committees

a. Member, School of Medicine Safety Committee

b. Member, Admission Committee, SIU School of Medicine

c. Principal Drug Control Officer, SIU school of Medicine

d. Member, Graduate Program Development Committee

e. Pharmacology Coordinator, 2nd year Medical Student Electives Committee

f. Member, Departmental of Radiology Review Committee (1983)

g. Member, Apprentice Program Advisory Committee

h. Department of Pharmacology Seminar Program Coordinator

i. Chair, Review Committee for Dept of Medical Microbiology and

Immunology (1984)

j. Member, Standard and PBL Sophomore Medical Curriculum Committees

k. Member, Department of Family Practice Review Committee (1985-86)

l. Director and Member, Pharmacology Graduate Program Committee

m. Member, International Relationship Committee (1987- 2002)

n. Member, Pattern Right Committee (1993-2002)

o. Director, SIU/Sun Yat-Sen University of Medical Science Affairs (1987-2002)

p. Member, Laboratory Animal Medicine Committee

q. Co-director for cardiovascular/renal/respiratory segment design group for

PBLC

r. Member, Year two PBLC Committee

2 5.

Ad hoc member, PBLC Examination Committee

Chair, Grievance Committee (1999-2001)

Ad hoc Member, The National Science Council Advisory Committee on

National Science and Technology Program in Pharmaceuticals and

Biotechnology, Taiwan. March 2002.

3. Editor North American Editor of Japanese Journal of Pharmacology, 1997-2002 Editor Emeritus Japanese Journal of Pharmacology, October, 2004-

4. Editorial and Grant Review Experience

a. Editorial Board Member

1. Journal of Pharmacology and Experimental Therapeutics (1982-1992)

2. Blood Vessels (1986-1992)

3. Cephalalgia

4. Chinese Journal of Pharmacology and Toxicology

b. Member, NIH Experimental Cardiovascular Sciences Study Section (1993-

1997)

c. Manuscript Reviewer for Artery, Science, Life Sciences, Circulation

Research, American Journal of Physiology, Journal of Cerebral Blood Flow

and Metabolism, Journal of Clinical Investigation, Neuropharmacology, J

Biomed Sci, Brain Research, J Neuroscience, Stroke, J Applied Physiol, J

Pharmacol Epx Ther

d. Research Grant reviewer for SIU Internal Funds (1976-2002)

e. Grant reviewer for Illinois Heart Association (1976-2001)

f. Ad hoc grant reviewer for NIH

g. Member, Medical Biotechnology Advisory Committee of The National

Health Research Institute (NHRI) of Taiwan (1992-1994)

h. Research grant proposal reviews for Research Grant Council (RGC),

Department of Health, Hong Kong (1996-2002)

1. Cerebral and peripheral vascular function in health and disease (transmitter, smooth

muscle, and endothelial interaction): pharmacology, biochemistry, molecular biology,

immunocytochemistry and immunoelectronmicroscopy.

2. Identification and clarification of the neurovascular transmitter

3. Natural products and the vascular functions

1. Nature of vasodilator and constrictor transmitters in the cerebral autonomic nervous

system

2. Regulation of nitric oxide release in cerebral perivascular nerves and the endothelium

3. Herbal medicines/natural products in the treatment of sepsis related diseases.

4. alpha7-nicotinic acetylcholine receptors in regulation of cerebral vascular function in

health and disease

3 s. t. u.

1. Principal Investigator: Research grant award from Illinois Heart Association,

1976-78, $20,000.

2. Principal Investigator: Research grant award from Illinois Heart Association,

1978-80, $20,000.

3. Principal Investigator: SIU Central Research Grant, 1977-79 ($25,000); 1979-80

($12,000); 1980-81 ($15,000); 1981-82 ($20,000); 1984-85 ($12,000); 1988-89

($5,000).

4. Principal Investigator: Research grant award from NIH, 1981-85, $123,871,

"Cerebral vessel innervation in hypertension".

5. Principal Investigator: Research grant award from American Heart Association,

September, 1983-August, 1987, $111,540.

6. Principal Investigator: Research grant award from American Heart Association,

September 1, 1985 - August 31, 1986, $33,000.

7. Principal Investigator: Research grant award from NIH 1985-1987 Nerve and Muscle

in Mesenteric and Pulmonary Vessels, $92,000.

8. Principal Investigator: Research grant award from Illinois Heart Association 1987-

1989, $30,000.

9. Principal Investigator: Research grant from NIH, 1985-1991 "Cerebral Vessel

Innervation in Hypertension."

10. Title of research project: "Cerebral serotonergic neurovascular transmission",

$1,800/year, 1990-1992, principal investigator. Illinois Heart Affiliate.

11. Title of research project: "Cerebral serotonergic neurovascular transmission",

$18,000/year for 2 years, sponsored fellowship, 1990-1992. Illinois Heart Affiliate.

12. Title of research Project: "ACE inhibitors in prevention of atherosclerosis

formation", $40,000/yr for 1 year, Sponsored Fellowship 1992-1993. Hoechst

Pharmaceuticals.

10. Title of research project: "aminoacidergic mechanisms and cerebral blood vessel

tone", $115,200, 1991-1994, principle investigator. American Heart Association.

(91010850)

11. Title of research project: "Mechanism of cerebrovascular hyporesponsiveness in

septic shock", $36,000, CRC, July 1997-June 1998

12. Title of research project: "Neurogenic control of coronary arterial tone", $5,000,

Fraternal Order of Eagles.

13. Principal Investigator: Research grant from NIH (HL 27763), 1991-1998 "Cerebral

Vessel Innervation in Hypertension."

14. Title of research project: "Cerebrovascular nitric oxidergic innervation". Source of

support: NIH (HL47574); period covered: July 1, 1993-December 2001 (no cost

extension), principal investigator.

15. Title of research project: “Cerebrovascular function in endotoxemia” $69,902, 1998- 2000. American Heart Association. July 1, 1998- June 30, 2001.

Principle Investigator

16. Title of research project: "Nicotine and cerebral vascular tone regulation", $53,000, SIU/CRC/EAM, August 1, 2000-August 31.2001.

17. Title of research project: "Cerebral vessel innervation in hypertension"; Amount of award: Direct cost for the entire period requested $550,000. 1999-2004. Source of support: NIH (HL 27763); period covered: July, 1999-June 30, 2004, principal investigator.

18. Title of research project: "Cerebrovascular nitric oxidergic innervation". Amount of

award: Direct cost for the entire period $925,000. Source of support: NIH (HL47574); period covered: December 2001-November 2005, principal investigator.

Current grant awards:

i) Title of research project: “Cerebrovascular sympathetic ?7-nicotinic

acetylcholine receptor: blockade by cholinesterase inhibitors”. Amount of

award: direct cost for the entire period NTD$3,600,000. Source of support:

National Science Council (NSC). Period covered: August 2003-July, 2006.

Principal investigator

ii) Title of research project: “Ketamine inhibition of ?7-nAChR-mediated

cerebral neurogenic vasodilation”. Amount of award: direct cost for the entire

period NTD$2,400,000. Source of support: National Science Council (NSC).

Period covered: August 2004-July, 2007. Principal investigator

iii) Title of Research project: “東台灣奈米科技研究中心”. A center program

project in collaboration with Tung-Hwa National University (PI) in Hualien.

Amount of award: total direct cost for the entire period NT$75,000,000, and

award to TCU (co-PI) for the first and second years is NT$14,000,000.

Source of support:國家科學委員會自然科學發展處 (Department of Natural

Sciences, NSC). Period of support: August 1, 2005–July 31, 2008. TCU

organizer: TJF Lee

Title of Research: “New botanical drug development”. Amount of award:

NT$2,200,000. Source of support: SunTen Phytotech Co., Ltd. Period of

support: August 1, 2005–July 31, 2009. Principal investigator. iv)

Lee TJF and Yang LL

U.S. 6,806,257

Approved date: 10/15/04

Title of Invention: Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators

Predoctoral (as the major advisor)

Matthew Linnik (Ph.D. 1986). Current position: Executive Vice President, La Jolla

Pharmaceutical Com, S. D., California

Frederic Jia-Pei Miao, M.D. (Ph.D. 1990). Current position: Senior pharmacologist at

Genetics

Samuel D. Shillcutt, Pharm D. (Ph.D. 1991). Current position: Professor and Director of

Psychopharmacology Lab, Mercer University School of Medicine, Macon, Georgia

F.Y. Chen, M.D. (Ph.D. 1995). Current position: Associate Professor, Dept of Pharmacology,

Michigan State University

J. Liu, M.D. (Ph.D. June, 1999). Current position: Research fellow, University of Chicago

R. Mishra, M.D. (Ph.D. June 2001). Dimera Incorporated, Portland OR

V. Jadhav, M.D. (Ph.D. July 2004): postdoctoral fellow, Loma Linda University

Mansoor Mozayan, M.D. (PhD student)

Kevin H Lin (PhD student)

Tzu-ling Tzeng (PhD student)

SC Chang (PhD student)

YJ Lee, M.D. (PhD student)

Kung MS, Lin SY, Liu YC, ---10 master degree students

Predoctoral (as committee member)

D Linville (PhD. 1992), E Messamore (PhD. 1992), W Qin (PhD. 1992), K Youngblood

(PhD. 1993), Z Nie (PhD. 1997), M Ford (PhD. 1997), E Schlorff (MS. 1997), S Abott (MS. 1997), Y Li (PhD. 1997), ML Si (PhD. 1999), K Hardiek (PhD. 1999), KY Chong (PhD. 1999), S Mishra (PhD. 2001), HJ Feng (PhD. 2001), S Pingle (PhD candidate), M Raisinghani (PhD candidate). 2 PhD and 3 MS (Taipei Medical University) and 2 PhD and 2 MS students at TCU (2003-2005)

Postdoctoral fellows: address in parenthesis indicates current address

Hiromasa Araki, Ph.D. (Director, R and D. Fuso Pharmaceutical Industries, Osaka, Japan) Akira Saito, Ph.D. (University of Tsukuba School of Medicine, Tokyo, Japan)

Jia-Yi Wang, Ph.D. (Professor, National Defense Medical Center, Taipei, Taiwan)

Satoru Fukuda, M.D. (Prof and Chair, Dept of Anesthesiology, Fukui Medical Univ, Japan) Tatsuo Tsuji, D.D.S., Ph.D. (Yamaguchi University School of Dentistry, Yamaguchi, Japan) Yasufumi Shirasaki, Ph.D. (Senior pharmacologist, Daiichi Eisai, Tokyo, Japan)

Jun-Ge Yu, M.D. (Academy of Traditional Chinese Medicine, Beijing, China)

Harumichi Imai, M.D. (Wakayama Medical School, Wakayama, Japan)

N. Sunagane, Ph.D. (Tokyo Science University, Tokyo, Japan)

Yun-Xiang Fang, M.D. (Hunan Medical University, Hunan, China)

T. Okuno, M.D. (Wakayama Medical School, Wakayama, Japan)

M. Ueno, M.D. (Wakayama Medical School, Wakayama, Japan)

Yujiro Asada, M.D. (Chair, Dept of Pathology, Miyazaki Medical College, Miyazaki, Japan) Takaaki Ishine, Ph.D. (Director, Clinical Studies, Banyou Pharmaceuticals, Tokyo)

M.H. Sun, M.D.(Sun Yat-sen University of Medical Sciences)

Eiki Satoh, Ph.D. (University of Obihiro, Obihiro, Japan)

Takafumi Kimura, M.D. (Gifu Medical University, Gifu, Japan)

W.H. Zhang, M.D. (Suzhou Medical University/Lund University, Sweden)

Yen-chou Chen, Ph.D. (Associate professor, Taipei Medical University)

Crystal Wang, Ph.D. (Associate professor, Taipei Medical University)

Minliang Si, PhD (southern Illinois University)

Cheng Long, PhD (Baylor University)

Visiting Scholars:

Professor Xiu Chen, M.D. (1992-1994) Hunan Medical College, Hunan, China

Professor L. Edvinsson M.D., Ph.D., Dept of Internal Medicine, Lund University, Sweden Professor L L Yang, Ph.D. Institute of Pharmacognosy, Taipei Medical College, Taipei

Dr Tony Jabre, M.D. Boston University, July 2001, July 2002

1. Second International Symposium on Vascular Neuroeffector Mechanism, Odense, Denmark,

1975.

2. First International Symposium on Brain Circulation, Stockholm, Sweden, 1977.

3. Symposium on Cerebral Blood Flow: Effect of nerves and neurotransmitters. Iowa City,

Iowa, June 16-18, 1981.

4. Tenth International Symposium on Cerebral Blood Flow and Metabolism, St. Louis,

Missouri, June 19-23, 1981.

5. 11th International Symposium on Cerebral Blood Flow and Metabolism, Paris, France, 1983.

6. Vasodilator Mechanisms in Cerebral Circulation, FASEB Meeting, Anaheim, California,

1985.

7. Eric K. Fernstrom Symposium on Neural Regulation of Brain Circulation, Lund, Sweden,

1985.

8. 5th International Symposium on SHR and Related Studies, Kyoto, Japan, 1985.

9. Symposium (Honoring the Retirement of Professor C.Y. Lee) on Recent Advances in

Pharmacology, Taipei, Taiwan, 1985.

10. Mechanism of Vasodilation IV, Rochester, Minnesota, July 10-12, 1986.

11. 6th International Symposium on Vascular Neuroeffector Mechanisms, Melbourne, Australia,

August 30-September 2, 1987.

12. 21st General Meeting of Japanese Pharmacology Society, Fukuoka, Japan, March 23-26,

1988.

13. First International Symposium on Biopeptide and Circulation, Fuzhou, China, July, 1988.

14. International Symposium on Biosignalling in Cardiac and Vascular System, Kyoto, Japan,

September, 1988

15. Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June 3-6,

1989.

16. International Symposium on Cerebral Vasospasm, Tokyo, Japan, May 16-18, 1990.

17. Symposium on Structure and Function of Blood Vessels, American Physiology Scoeity and

Chinese Physiology Society Joint Meeting, Taipei, Taiwan, November 2-5, 1990.

18. International Society for Heart Research (ISHR) Cincinnati, Ohio, June, 1991

19. Parasympathetic Innervation in Cerebral Blood Vessels Workshop, Brain, 1991, Miami,

Florida.

20. FASEB Symposium: Mechanism of Vasodilation: Neuronal and Myogenic Origins.

Anaheim, California, 1992.

21. Second Japanese Symposium on Cerebral Blood Vessels, Osaka, Japan, August 29, 1992.

22. The Human Brain Circulation: Functional Changes in Disease, Basin Harbor Club,

Vergennes, Vermont, October 4-7, 1992.

23. International Symposium on Cerebral Blood Vessels, Zao, Japan, June 1993.

24. Neurobiology of NO and OH, Washington, DC, November 7, 1993.

25. International Symposium on hypertension and stroke. Tzu-Chi Medical College, Hualien,

Taiwan, December 3-5, 1993.

26. FASEB Summer Conference on Nitric Oxide, Saxton River, Vermont, July, 1994.

27. Western Pharmacology Society Symposium on Nitric Oxide, Maui, Hawaii, Jan. 22-25,

1995.

28. Sino-Japanese Annual Pharmacological Meeting, Kyoto, Japan, December 3-5, 1995.

29, Stroke and Cerebral Blood Flow and Metabolism Symposium, Taichung, Taiwan, Dec, 1995.

30. Drug Research and Development Symposium, Taipei, Taiwan, December 17-19, 1995.

31. 7th International Headache Research Seminar, Copenhagen, November 22-24, 1996.

32. Annual Meeting of Japanese Society of Anesthesiology, Niigata, Japan, April, 1997.

33. International Symposium on Mechanism of Cerebrovascular Function and Regulation,

Williamsburg, Virginia, June, 1997.

34 Tenth Asian-Australian Congress of Anesthesiologists. “NO, Anesthetics, and Cerebral

Vascular Function”, Taipei, Taiwan, May 10-14, 1998

35 Summer School ’98 of The International Society of Cerebral Blood Flow and Metabolism, Tokyo, Japan, June 28-July 1, 1998

36. IUPHAR 98 Munich, Vascular Neuroeffector Workshop. July, 1998

37. Annual Neuroscience Meeting, Taipei, Taiwan. October, 1998

38. Integrative Medicine: An International Conference Exploring Alternative Treatments In The Eastern and The Western Cultures. Springfield, IL April 6, 1999

39. 10th Symposium on deficits in higher brain function, Tokyo, Japan, September 3-4, 1999

40. IUPHAR SEAWP (8th Southeast Asia-Western Pacific Regional Meeting of Pharmacology, Taipei, Taiwan, November 1-5, 1999

41. Annual Japanese Pharmacology Society Meeting, Yokohama, March 21, 2001

42. 2nd TWGH Eddie Wang Symposium on complementary Chinese and Western medicine, November 28-30, 2001, Hong Kong

43. 10th International Symposium on Vascular Neuroeffector Mechanisms, Granlibakken Conference Center, Lake Tahoe, California. July 12-15, 2002,

44. Symposium on vascular function: smooth muscle and endothelial cells. Kinki University, Japan, May 10-12, 2003

45. The 1st TMU Neuroscience Symposium, Taipei, Taiwan, September 17-18, 2004 46. Neuroprotection symposium, National Taiwan University, 2004

47. Symposium on Physiology and Pharmacology at the 20th Joint Annual Conference of

Biomedical Sciences. Taipei, Taiwan, March 27, 2005

48. Twentieth Natural Product Symposium, June 24-25, 2005, NRICM, Taipei

49. First Asian Society of Vascular Biology (ASVB), October 8-10, 2005, Shanghai, PRC

ORGANIZATION OF SYMPOSIUM AND SPECIAL LECTURES

1. Springfield Blood Vessel Symposium - Basic and Clinical Aspects, August 23, 1983, Springfield, IL (co-organizer)

2. Springfield Blood Vessel Symposium in memory of Che Su - Neurohumoral Control of blood Vessel Tone, April 12-13, 1986, Springfield, IL (Organizer)

3. Mechanisms of Vascular Tone Regulation - Joint Meeting of American Physiology Society (APS) and Chinese Physiology Society, Taipei, Taiwan, October, 1990 (Organizer)

4. Mechanisms of Vasodilation: Neuronal and Myogenic Origins, FASEB Symposium, Anaheim, California, April, 1992 (Organizer)

5. Annual Che Su Memorial Lectures, 1987 -

6. International Symposium: Perspectives of Chinese and American Medicine. Sun Yat-Sen University of Medical Sciences, Guangzhou, China, 1987, 1988, 1989, 1991, 1992 (Organizer) Healthcare for the Twenty-First Century: Eastern and Western Perspective, June13-15, 1996, Springfield, Illinois (Organizer)

7. International Symposium: Mechanism of Cerebrovascular Function and Regulation. Williamsburg, Virginia, June 21-22, 1997 (Organizer)

8. International Symposium on research and new drug development. November 6, 1999, Taipei

9. XXth International Symposium on Cerebral Blood Flow and Metabolism (Brain 2001),

and Vth International Conference on Quantification of Brain Function with PET, Taipei, Taiwan, June 9-13, 2001 (Main Organizer)

10. 4th TBA symposium “stem cells”. Nov 10, 2001, Society of Neuroscience Meeting, San Diego (co-organizer)

11. International Symposium on Brain Activation and CBF Control, Tokyo, Japan, June 6-7 2001 (Co-organizer)

12. Symposium on Physiology and Pharmacology at the 20th Joint Annual Conference of

Biomedical Sciences. Taipei, Taiwan, March 27, 2005

13. Biomedicine and Humanity Symposium. Tzu Chi University, November 2005

14. 11th International Symposium on Vascular Neuroeffector Mechanisms, June, 2006, Shanghai,

15. Chair person for the Symposium on “Presynaptic receptor, 3rd decade, and Future

perspective” at International Union for Pharmacology (IUPHAR), Beijing, July 2006

American Men and Women of Science, Physical and Biological Sciences, 1979.

Who's Who in Technology Today, 3rd Edition, Vol. 6, Biomedical, Energy and

Related Disciplines, 1982.

Who's Who in Frontier Science and Technology, 1st Edition, 1984-present

Who's Who in the World, 1984-present

1. Yen KY, Lee WH and Lee JF (1967) Studies on the pharmacological effective components of local plants in Taiwan (II) - The antibiotic activity and pharmacological action of AmPeloPsis baeviHedunculata Traut. var. hancei Li. J. Taiwan Pharmaceut. Assoc. 19:15-20

2. Thomas JA, Mawhinney MG, Smith CG and Lee TJF (1971) The action of testosterone on the assimilation of non-metabolizable hexoses by the prostate. J. Pharmacol. Exp. Ther. 179:499-504

3. Lee, TJF and Bevan JA (1974) The effect of nerve stimulation and pharmacological agents on the contractile activity of the isolated basilar artery of the rabbit. Proc. West. Pharmacol. Soc. 17:129-131

4. Duckles SP, Lee TJF and Bevan JA (1974) Histamine potentiation of contractile responses of rabbit basilar artery. Proc. West Pharmacol. Soc. 17:118-121

5. Lee TJF, Westfall DP and Fleming WW (1975) The correlation between spontaneous contractions and postjunctional supersensitivity of the smooth muscle of the rat vas deferens. J. Pharmacol. Exp. Ther. 192:136-148

6. Westfall DP, Lee TJF and Stitzel RE (1975) Morphological and biochemical changes in supersensitive smooth muscle. Fed. Proc. 34:1985-1989

7. Bevan JA, Duckles SP and Lee TJF (1975) Histamine potentiation of nerve- and drug-induced responses of a rabbit cerebral artery. Cir. Res. 36:647-653

8. Lee TJF, Su C and Bevan JA (1975) Nonsympathetic dilator innervation of cat cerebral arteries. Experientia 31:1424-1425

9. Lee TJF, Su C and Bevan JA (1976) Neurogenic sympathetic vasoconstriction of the rabbit basilar artery. Cir. Res., 39:120-126

10. Westfall DP, Millecchia LL, Lee TJF, Corey SP, Smith DJ and Fleming WW (1977) Effects of denervation and reserpine on nexuses in the rat vas deferens. Eur. J. Pharmacol., 41:239-242

11. Lee TJF, Hume WR, Su C and Bevan JA (1978) Neurogenic vasodilation of cat cerebral arteries. Cir. Res., 42:535-542

12. Lee TJF, Chiueh CC and Adams M (1980) Synaptic transmission of vasoconstrictor nerves in the rabbit basilar artery. Eur. J. Pharmacol. 61:55-70.

13. Lee TJF (1980) Direct evidence against acetylcholine as the dilator transmitter in the cat cerebral artery. Eur. J. Pharmacol. 68:393-394

14. Lee TJF, Araki H and Su C (1981) Tyramine-induced contractions in the rabbit ear and basilar arteries. J. Cardiovascular Pharmacol., 3:965-976

15. Lee TJF (1981) Is acetylcholine the dilator transmitter in cerebral blood vessels? A critical examination. Proceedings of Tenth International Symposium on Brain Circulation and Metabolism. J. Cerebral Blood Flow Metabol. 1(suppl):S305-306

16. Lee TJF (1981) Ultrastructural distribution of vasodilator and constrictor nerves in cat cerebral arteries. Circ. Res. 49:971-979

17. Lee TJF (1982) Cholinergic mechanisms in the large cat cerebral arteries. Circ. Res., 50:870-379

18. Araki H, Su C and Lee TJF (1982) Effect of superior cervical ganglionectomy on the sensitivity of rabbit ear artery and cerebral arteries of rabbit and cat to vasoactive agents. J Pharmacol Exp Ther 220:49-55

19. Lee TJF, Kinkead L and Sarwinski S (1982) Norepinephrine and acetylcholine transmitter mechanism in pig cerebral blood vessels. J Cereb Blood Flow Metab 2:439-450

20. Saito A and Lee TJF (1983) Autonomic innervation of the brain arteries in renal hypertensive rats. J. Cereb Blood Flow Metab, 3, Suppl. 1:S192-S193

21. Lee TJF and Saito A (1984) Altered cerebral vessel innervation in the spontaneously hypertensive rat. Circ. Res., 55:392-403

22. Lee TJF, Saito A and Beresin I (1984) Vasoactive intestinal polypeptide-like substance: The potential cerebral vasodilator transmitter. Science 224:898-901

23. Lee TJF, McIlhany MP and Sarwinski S (1984) Erythrocyte extracts enhance neurogenic vasoconstriction of cerebral arteries in vitro. J Cereb Blood Flow Metab, 4:474-476

24. Edvinsson L, Birath E, Uddman R, Lee TJF, MacKenzie ET, Scantton B and Duverger D (1984) Indoleaminergic mechanisms in brain vessels: Localization, concentration, uptake and in vitro responses of 5-hydroxytryptamine. Acta Physiol Scand, 121:291-299

25. Saito A and Lee TJF (1985) Autonomic innervation of cerebral blood vessels decreases in renal hypertensive rats. Hypertension 7:514-518

26. Saito A, Wu JY and Lee TJF (1985) Evidence for the presence of cholinergic nerves in cerebral arteries. An immunohistochemical demonstration of choline acetyltransferase. J Cereb Blood Flow Metab 5:327-334

27. Fukuda S., Su C and Lee TJF (1986) Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery. J Cardiovasc Pharmacol 8:765-770

28. Fukuda S, Su C and Lee TJF (1986) Mechanisms of extraneuronal serotonin uptake in the rat aorta. J Pharmacol Exp Ther 239:264-269.

30. Fukuda S, Su C and Lee TJF (1986) Extraneuronal serotonin accumulation in peripheral arteries of the rat. Experientia 42:1244-1245

31. Wang JY and Lee TJF (1986) Beta-receptor-mediated vasodilation in cerebral arteries of the pig. Acta. Physiol. Scand., 127 (Suppl. 552):41-44

32. Linnik MD and Lee TJF (1986) Oxyhemoglobin inhibition of acetylcholinesterase activity. Neurosci. Ltr., 66:159-162

33. Lee TJF and Saito A (1986) Altered cerebral vessel innervation in spontaneously hypertensive and renal hypertensive rats. J Hypertension 4 (Suppl. 3): S201-S203, 1986.

34. Shirasaki Y, Su C, Kolm P, Lee TJF, Cline WH Jr and Nickols GA (1986) Endothelial modulation of vascular relaxation to nitrovasodilators in aging and hypertension. J Pharmacol Exp Ther 239:861-866

35. Saito A and Lee TJF (1987) Serotonin as an alternative transmitter in sympathetic nerves in large cerebral arteries of the rabbit. Circ Res 60:220-228

36. Urabe M, Su C and Lee TJF (1987) Pre- and postsynaptic effects of angiotensins in femoral artery of SHR and WKY. Blood Vessels 24:1-10

37. Lee TJF (1987) Altered endothelium modulation of vascular tone in aging and hypertension. Blood Vessels 24:132-136

38. Higashino H, Suzuki A, Su C and Lee TJF (1987) Role of endothelial cells in responses of spontaneously hypertensive rat mesenteric arteries to norepinephrine angiotensins. Jpn. J. Smooth Muscle Res 23(6):449-56

39. Shirasaki Y, Kolm P, Nickols GA and Lee TJF (1988) Cyclic GMP involvement in the

endothelial regulation of vascular responses to norepinephrine and acetylcholine in hypertension. J Pharmacol Exp Ther 245:53-58

40. Saito A, Masaki T, Lee TJF and Goto K (1988) Effects of capsaicin on the contractility and peptide-containing nerves of large cerebral arteries of the cat. Arch Int Pharmacodyn 295:194-203

41. Tsuji T, Su C and Lee TJF (1989) Enhanced presynaptic beta-2 adrenoceptor-mediated facilitation of the pressor responses in the prehypertensive SHR. J Cardiovascular Pharmacol 14:737-746.

42. Yu JG and Lee TJF (1989) 5-hydroxytryptamine-containing fibers in cerebral arteries of the cat, rat and guinea pig. Blood Vessels 26:33-43

43. Saito A, Masaki T, Uchiyama Y, Lee TJF and Goto K (1989) Calcitonin gene-related peptide (CGRP) and vasodilator nerves in large cerebral arteries of cats. J Pharmacol Exp Ther 248:455-462

44. Linnik MD and Lee TJF (1989) Effects of hemoglobin on neurogenic responses and cholinergic parameters in porcine cerebral arteries. J Cereb Blood Flow Metab 9:219-225

45. Miao FJP and Lee TJF (1989) Effects of billirubin on cerebral arterial tone Blood Flow Metab 9:666-674

46. Maio FJP and Lee TJF (1990) Cholinergic and VIPergic innervation in cerebral arteries: A sequential double-labelling immunohistochemical study. J Cereb Blood Flow Metab 10:32-37

47. Fukuda S, Matsumoto M, Nishimura N, Fujiwara N, Shimoji K, Takeshita H and Lee TJF (1990) Endothelial modulation of norepinephrine-induced constriction of the rat aorta at normal and high CO2 tension. Am J Physiol 258:H1049-H1054

48. Imai I, Okuno T, Wu JY and Lee TJF (1991) GABAergic innervation in cerebral blood vessels: An immunohistochemical demonstration of L-glutamic acid decarboxylase and GABA transaminase. J Cereb Blood Flow Metab 11:129-134

49. Miao FJP and Lee TJF (1991) VIPergic and cholinergic innervations in internal carotid arteries of the cat and rat. J Cardiovascular Pharmacol 18:369-378

50. Lee TJF and Sarwinski S (1991) Nitric oxidergic neurogenic vasodilation in basilar arteries of the pig. Blood Vessels 28:407-412.

51. Miao FJP and Lee TJF (1992) Regional variation in acute vascular homologous tachyphylaxis. J Pharmacol Exp Ther 260:644-651

52. Yu JG, Wu JY and Lee TJF (1992) Choline Acetyltransferase-immunoreactivities in cerebral blood vessels. Chinese J Pharmacol Toxicol. 6:28-35

53. Linnik MD and Lee TJF (1992) Cholinergic vasoconstriction in cat cerebral arteries. Chinese J Pharmacol Toxicol 6:19-27.

54. Lee TJF (1992) Sympathetic vasoconstriction of the rabbit ear artery: partial resistance to alpha-adrenergic receptor antagonists. Chinese J Pharmacol Toxicol 6:14-18

55. Asada Y and Lee TJF (1992) ?2-adrenoceptor-mediated constriction of porcine pial veins. Am J Physiol 263:H1907-H1910

56. Chen FY and Lee TJF (1993) Role of nitric oxide in neurogenic vasodilation of porcine cerebral artery. J Pharmacol Exp Ther 265:339-345

57. Linnik MD and Lee TJF (1993) Effects of hemoglobin on sympathetic neurovascular transmission in the porcine cerebral circulation. J Cardiovasc Pharmacol 21:615-620

58. Ueno M and Lee TJF (1993) Endotoxin decreases the contractile responses of the porcine basilar artery to vasoactive substances. J Cereb Blood Flow Metab 13:712-719

59. Tsuchiya K, Urabe M, Yamamo R, Asada Y and Lee TJF (1993) Effects of L-Nw-nitro-arginine and capsaicin on neurogenic vasomotor responses in isolated mesenteric arteries of the monkey. J Pharmacy Pharmacol 46:155-157

60. Lee TJF, Ueno M, Sunagane N and Sun MH (1994) Serotonin relaxes porcine pial veins. Am J Physiol 266:H1000-H1006

61. Okuno T, Itakura TL, Lee TJF, Masami U, Shimizu M and Komai N (1994) Cerebral pial arterial innervation with specific reference to GABAergic innervations. J Autonomic Nervous Sys 49:S105-S110

62. Ueno M, Ishine T and Lee TJF (1995) A novel 5HT1-like receptor subtype mediates cAMP synthesis in the porcine pial vein. Am J Physiol 268:H1383-H1389.

63. Chen X and Lee TJF (1995) Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 115:15-18

64. Chen FY and Lee TJF (1995) Arginine synthesis from citrulline in perivascular nerves of cerebral arteries. J Pharmacol Exp Ther 273:895-901

65. Guo LJ, Qu L and Lee TJF (1995) Effects of ?-aminobutyric acid on isolated dog cerebral arteries. Acta Pharmaceutica Sinica 30:573-576.

66. Nomura S, Sunagane N, Lee TJF, Uruno T and Kubota K (1995) Inhibition of alpha-adrenoceptor-mediated contraction in isolated tail arteries and aorta of the rat by alpha 2-adrenoceptor agonists. Res Com Molecular Path Pharmacol 90(3):307-320

67. Lee TJF, Sarwinski S, Ishine T, Lai C and Chen FY (1996) Inhibition of cerebral neurogenic vasodilation by L-glutatmine and nitric oxide synthase inhibitors. J Pharmacol. Exp Ther 267:353-358

68. Ishine T and Lee TJF (1996) Norepinephrine attenuates serotonin inhibition of pial venous tone. Eur J Pharmacol 313:97-102

69. Yamamoto R, Wada A, Asada Y, Yanagita T, Yuhi T, Niina H, Sumiyoshi A, Kobayashi H and Lee TJF (1997) Nitric oxide-dependent and -independent norepinephrine release in the rat mesenteric arteries. Am J Physiol 272:H207-H210

70. Yu JG, O’Brien WE and Lee TJF (1997) Morphological evidence for L-citrulline conversion to L-arginine via the argininosuccinate pathway in porcine cerebral perivascular nerves. J Cereb Blood Flow Metab17:884-893

71. Sun MH, Ishine T and Lee TJF (1997) Dopamine constricts porcine pial veins. Eur J Pharmacol 334:165-171

72. Kimura T, Yu JG, Edvinsson L and Lee TJF (1997) Cholinergic, nitric oxidergic innervation in cerebral arteries of the cat. Brain Res. 773:117-124

73. Yu JG, Ishine T, Kimura T, O’Brien WE and Lee TJF (1997) L-citrulline conversion to L-arginine in sphenopalatine ganglia and cerebral perivascular nerves in the pig. Am J Physiol 273:H2192-H2199

74. Asada Y, Yu JG and Lee TJF (1997) Myo-endothelial junctions in endothelium-dependent vasodilation. Cell Vision 4:308-317

75. Chen X, Sarwinski S and Lee TJF (1997) Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin Exp Pharmacol Physiol 24:958-959

76. Zhang W, Edvinsson L and Lee TJF (1998) Mechanism of nicotine-induced relaxation in the porcine basilar artery. J Pharmacol Exp Ther 284:790-797

77. Yu JG, Kimura T, Chang XF, and Lee TJF (1998) Segregation of VIPergic-nitric oxidergic and cholinergic-nitric oxidergic innervation in porcine middle cerebral arteries. Brain Res 801:78-87

78. Chen X, Liu LY and Li ZF (Lee TJF) (1998) Cardiovascular protective effects and NO-mediated cerebrovasorelaxant effects of extract of Ginkgo biloba leaves. Natl Med J China 78: 692-695 (with English abstract).

79. Liu J and Lee TJF (1999) Mechanism of Prejunctional Muscarinic Receptor-mediated Inhibition of Neurogenic Vasodilation in Porcine cerebral Arteries. Am J Physiol 276: H194-H204

80. Ishine T, Yu JG, Asada Y and Lee TJF (1999) Nitric oxide is predominant mediator for

neurogenic vasodilation in the porcine pial veins. J Pharmacol Exp Ther 289:398-404

81. Liu J, Evans SM, Brewer GJ and Lee TJF (2000) N-type Ca2+-channels in Cultured Rat Sphenopalatine Ganglion Neurons: An Immunohistochemical and Electrophysiological study. J Cereb Blood Flow Metab 20:183-191

82. Lee TJF (2000) Nitric Oxide and the Cerebral Vascular Function. J Biomed Sci 7:16-26

83. Ishine T, Bouchelet I, Hamel E and Lee TJF (2000) Serotonin 5HT7 receptors mediate relaxation of porcine pial veins. Am J Physiol 278: H907-H912

84. Chen YC, Yang LL and Lee TJF (2000) Oroxylin A Inhibition of LPS-induced iNOS and COX-2 Gene Expressions via Suppression of NF-kB Activation. Biochem Pharmacol 59: 1445-1457

85. Lee TJF, Zhang W and Sarwinski S (2000) Presynaptic beta2-adrenoceptors mediate nicotine-induced NOergic neurogenic vasodilation in the pig cerebral arteries. Am J Physiol Heart Circ Physiol. 279(2):H808-816

86. Lee TJF (2000) Identification of 5-HT receptor subtype mediating 5-HT-induced relaxation of porcine pial veins. Biomedical Res 11: 201-208

87. Chen YC, Shen SC, Chen LG, Lee TJF and Yang LL (2001) Wogonin, Baicalin, and Baicalein Inhibition of Inducible Nitric Oxide Synthase and Cyclooxygenase 2 Gene Expressions Induced by NOS inhibitors and Lipopolysaccharide. Biochem Pharmacol. 61(11):1417-27

88. Lee TJF, Liu J and Evans MS (2001) Cholinergic-nitrergic transmitter mechanisms in the cerebral circulation. Microsc Res Tech 53: 119-128

89. Edvinsson L, Elsas T, Suzuki N, Shimiza T and Lee TJF (2001) Origin and colocalization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat. Microsc Res Tech 53: 221-228

90. Si, ML and Lee TJF (2001) Presynaptic ?7-nicotinic acetylcholine receptors mediate nicotine-induced NOergic neurogenic vasodilation in porcine basilar arteries. J Pharmacol Exp Ther 298(1):122-128

91. Chen YC, Shen SC, Lee WR, Hou WC, Yang LL, and Lee TJF (2001) Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages. J Cell Biochem 82(4):537-48

92. Lee TJF (2002) Sympathetic modulation of nitrergic neurogenic vasodilation in cerebral arteries. Jap J Pharmacol 88:26-31.

93. Lee TJF and Yu JG (2002) L-citrulline recycle for synthesis of NO in cerebral perivascular nerves and endothelial cells. Ann N Y Acad Sci 962:73-80

94. Murphy LL and Lee TJF (2002) Ginseng, sex behavior and nitric oxide. Ann N Y Acad Sci 962: 372-377

95. Uchida S, Kawashima K, and Lee TJF (2002) Nicotine-induced NO-mediated increase in cortical CBF is blocked by ?2-adrenoceptor antagonists in the anesthetized rats. Autonomic Neurosci: Basic and Clinical 96(2):126-130

96. Liu J, Evans MS and Lee TJF (2002) Presynaptic muscarinic M2-receptor-mediated inhibition of N-type Ca2+ channels in cultured SPG: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. J Pharmacol Exp Ther 302(1):397-405

97. Si ML and Lee TJF (2002) ?7-nAChRs on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation. Circ Res 91(1):62-69

98. Chen YC, Shen SC, Lee WR, Lin HY, and Lee TJF (2002) Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gama-induced heme oxygenase1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. J Cell Biochem 86 (2): 331-339

99. Si ML and Lee TJF (2003) Pb2+ inhibition of sympathetic ?7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. J Pharmacol Exp Ther 305(3):1124-1131

100. Chen YC, Shen SC, Lin HY, Tsai SH, and Lee TJF (2004) nicotine enhancement of

lipopolysaccride/interferon-?-induced cytotoxicity with elevating nitric oxide production. Toxicol Lett 153:191-200

101. Jabre A, Jadhav VD, Lee TJF: Synergistic vasoconstriction of thromboxane A2 and oxyhemoglobin in the porcine basilar arteries. Proceedings in: Cerebral Vasospasm (Macdonald RL, ed). Published by Thieme, New York (in press).

102. Jadhav V, Jabre A, Lin SZ and Lee TJF (2004) EP1- and EP3-receptors mediate PGE2-induced constriction of porcine large cerebral arteries. J Cereb Blood Flow Metab 24 (12):1305-1316

103. Ching Huai Ko, Shing-Chun Shen, Tony J. F. Lee, Yen Chou Chen (2005) Myricetin inhibition of invasion via blocking MMP-2 protein expression and enzyme activity in colorectal carcinoma cells: suppression of TPA-induced ERK and PKC signal transduction. Mol Cancer Ther 4(2):281-290

104. Si ML, Long C, Yang DI, Chen MF, and Lee TJF (2005) Statins prevent ?-Amyloid inhibition of sympathetic ??-nAChR-mediated cerebral nitrergic neurogenic vasodilation. J Cereb Blood Flow Metab 25(12):1573-1585.

105. Long C, Si ML, Sarwingki SJ, Chen MF, Evans MS and Lee TJF: Monoamine uptake inhibitors block ?7-nAChR-mediated cerebral nitrergic neurogenic vasodilation (in press) Am J Physiol

106. Mozayan M, Si M, Chen MF, and Lee TJF. Cholinesterase inhibitors block sympathetic α7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries (in press) J Cereb Blood Flow Metab

107. Lin HW, Janutka JC, Hsu WL, and Lee TJF: Oroxylin A inhibits nicotine-induced angiogenesis (to be submitted)

108. Chen YC, Yang LL and Lee TJF: Oroxylin A Inhibition of LPS-induced iNOS Expression in Porcine Cerebral Arteries (submitted)

109. Mishra RG and Lee TJF: Bacterial endotoxin induced abbreviated urea cycle in porcine cerebral vascular smooth muscle (submitted)

1. Lee TJF and Stitzel RE: Adrenomimetic drugs. In: Modern Pharmacology (Craig, C.R. and Stitzel, R.E. eds), Little, Brown and Company, 4th Edition (1994), 5th Edition (1998), and 6th Edition (2004) Boston.

2. Lee TJF: Cholinergic interactions and vascular smooth muscle tone. In: Calcium and Smooth Muscle Contractility. (eds., E.E. Daniel and A.K. Grover), Humana Press, pp. 351-383, 1985.

3. Lee TJF: Cholinergic mechanisms in cerebral circulation. In: Trends in Autonomic Pharmacology (S. Kalsner, ed.), Vol. 3, pp. 187-202, 1985.

4. Lee TJF: Evidence for and against VIP as a transmitter for vasodilation in cerebral blood vessels. In: Peptidergic Mechanisms in the Cerebral Circulation (eds, L. Edvinsson and J. McCulloch), Ellis Horwood Limited, pp. 64-74, 1987.

5. Shillcutt SD, Lee TJF and Couch JR: Headache. In: Clinical Pharmacy and Therapeutics (E.T. Herfindal, D.R. Gourley and L.L. Hart, eds), William and Wilkins, Baltimore, pp. 552-569, 1988.

6. Lee TJF: Altered cerebral vessel innervation in hypertension. In: Blood Vessel Changes in Hypertension: Structure and Function VII (ed., R. Lee), CRC Press, pp. 1-18, 1989.

7. Lee TJF and Mishra R: Nitrergic neurogenic control of resistance blood vessels. In: Nitric oxide and Free radicals. Ed. S Kalsner. Birkhauser, New York, pp 160-182, 2000

1. Neurohumoral Control of Blood Vessel Tone. Blood Vessels, 24(3):89-168, 1987. An

international symposium held in Honor of Che Su, Springfield, IL, April 12-13, 1986. Ed. Lee TJF.

2. Lee TJF(2001) J Cereb Blood Flow Metab (guest editor For Brain ’01 meeting in Taipei)

3. Symposium on Mechanisms of Cerebrovascular Function and Regulation held in Williamsburg, VA, 1997. Eds Lee TJF and Pearce WJ. (Publisher: Yen’s Foundation, Taipei, Taiwan).

1. Su C and Lee TJF: Regional variation of adrenergic and nonadrenergic nerves in blood vessels. Second International Symposium on Vascular Neuroeffector Mechanism. University of Odense, Denmark, 1975, pp. 35-42 (Karger, Basel, 1976).

2. Duckles SP, Lee TJF and Bevan JA: Cerebral arterial responses to nerve stimulation in vitro. Species variation in the constrictor and dilator components. Proceedings of the International Symposium on Neurogenic Control of Brain Circulation, Stockholm, 1977, Wenner-Gren, Vol. 30, pp. 133-141 (Pergamon Press, 1977).

3. Araki H, Lee TJF and Su C: Comparative studies of sympathetic nervous control in cerebral and peripheral arteries. Proceedings of the Symposium of Japan Society of Neurovegetative Research, Kyoto, Japan. The Autonomic Nervous System, 18:288-291, 1981.

4. Lee TJF: Morphopharmacological studies of cerebral vasodilator and constrictor nerves. Proceedings of Symposium on Cerebral Blood Flow: Effect of nerves and neurotransmitters. Iowa City, Iowa, 1981, pp. 431-439, (eds., Heistad and Marcus), Elsevier North Holland.

5. Lee TJF: Transmitter mechanisms in cerebral arteries: Norepinephrine, acetylcholine, vasoactive intestinal polypeptide and substance P. Proceedings of Springfield Blood Vessel Symposium - Basic and Clinical Aspects. (eds., C. Su, T.J-F. Lee and W. Cline, Jr.), Springfield, IL, 1983, pp. 38-43.

6. Su C, Lee TJF and Cline Jr WH: Proceedings of Springfield Blood Vessel Symposium--Basic and Clinical Aspects. (Su C, Lee TJF and Cline WH, Jr., eds) Southern Illinois University School of Medicine, Springfield, IL, 1983

7. Lee TJF: Sympathetic and nonsympathetic transmitter mechanisms in cerebral vasodilation and constriction. Proc. Erin K. Fernstrom Symposium on Neural Regulation of Brain Circulation (eds.,

C. Owman et al.,), 1985, Elsevier Biomedical Press, pp. 285-296, 1986.

8. Lee TJF, Linnik MD, Shirasaki Y, Imai H, McIlhany MP and Yu JG: Neurogenic vasodilation in the cat cerebral arteries. In: Vasodilation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium (P.M. Vanhoutte, ed.), New York, Raven Press, 1988, pp. 101-106.

9. Lee TJF, Linnik MD and Miao FJP: Erythrocyte extracts and cerebral vascular function. In: Vascular Neuroeffector Mechanisms, (eds., J.A. Bevan, H. Majewski, R.A. Maxwell and D.F. Story), IRL Press, pp. 299-309, 1988.

10. Saito A, Kimura S, Uchiyamna K, Shoji T, Lee TJF and Goto K: Calcitonin gene-related peptide (CGRP) and blood vessel function. In: Vascular Neuroeffector Mechansims, (eds., J.A. Bevan, H. Majewski, R.A. Maxwell and D.F. Story), IRL Press, pp. 141-148, 1988.

11. Miao FJF and Lee TJF: Cholinergic and VIPergic innervations in cerebral arteries of the cat. In: J. Seylaz and E.T. MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 335-338, 1989.

12. Okuno T and Lee TJF: Morphological relationship between GABAergic and other autonomic innervations in brain arteries. In: J. Seylaz and E.T. MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 155-158, 1989.

13. Saito A, Mima T, Shigeno T, Lee TJF and Goto K: Role of calcitonin gene-related peptide (CGRP) as a vasodilator transmitter in large cerebral arteries of cats. In: J. Seylaz and E.T.

MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 281-284, 1989.

14. Lee TJF and Sunagane N: 5-HT1-like receptors mediate pial venous relaxation. In: J. Seylaz and MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 233-236, 1989.

15. Imai H, Itakura T, Komai N, Wu JY, Okuno T and Lee TJF: Immunohistochemical evidence for the presence of GABAergic nerves in cerebral blood vessels. In: J. Seylaz and E.T. MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 151-154, 1989.

16. Lee TJF, Fang YX and Nickols GA: Cyclic nucleotides and cerebral neurogenic vasodilation. In: J. Seylaz and E.T. MacKenzie (eds.) Neurotransmission and Cerebrovascular Function, Elsevier, pp. 277-280, 1989.

17. Lee TJF: Recent studies on serotonin-containing fibers in cerebral circulation. In: J. Seylaz and R. Sercombe (eds.), Neurotransmission and Cerebrovascular Function. Elsevier, pp. 133-149, 1989.

18. Lee TJF: Putative transmitters in cerebral neurogenic vasodilation. In: The Human Brain Circulation: Functional Changes in Disease (J.A. Bevan, & R.D. Bevan, , eds), Humana Press pp 73-91, 1994.

19. Lee TJF, Sunagane N, Saito A, Fukuda S and Yu JA: Serotonin-containing fibers in cerebral blood vessels. In: International Symposium on Biosignalling in Cardiac and Vascular Systems. (eds., Fujiwara, et al.) Pergamon Press, pp. 86-92, 1989.

20. Lee TJF and Tsuji T: Presynaptic-beta-adrenoceptor mediated facilitation of pressor response is enhanced in prehypertensive SHR. In: International Symposium on Biosignalling in Cardiac and Vascular System. (eds., Fujiwara, et al.,) Pergamon Press, pp. 362-364, 1989.

21. Lee TJF: Endothelial messengers and cerebral vascular tone regulation. In: Headache Pathogenesis: Monoamines, Neuropeptides, Purines, and Nitric Oxide (eds. J. Olesen and L. Edvinsson), Lippincott-Raven (Philadelphia, New York), pp61-72, 1997.

22. Lee TJF, Liu J and Evans MS: Cholinergic mechanisms in cerebral neurogenic vasodilation. Proceedings of the 10th Symposium on defects in higher brain function (ISSN 1344-6851), Tokyo, Japan, p51-56, 1999

23. Lee TJF: Adrenergic and cholinergic modulation of cerebrovascular nitrergic vasodilation. Excerpta Medica Int Congr Series 1235 (Tomita m, Kanno I, Hamel E), p. 337-345, 2002

Author of several curricular objectives in the area of cardiovascular and respiratory pharmacology. Curricular objectives, Southern Illinois University School of Medicine, 1980-

Farney, T. and Lee, T.J-F.: Glaucoma. Cataloged in PLATO Computer Health Sciences Network, University of Illinois, Urbana, Illinois, 1978.

Wenger GR, Thomas JA and Lee TJF: Effect of reserpine and cycloheximide on hexose levels in homogenates of mouse brain. Pharmacologist, 11:290, 1969.

Mawhinney MG, Lee TJF, Smith CC and Thomas JA: Uptake of 2-Deoxyglucose-14C and Lee TJF and Westfall DP: Spontaneous contractions in denervated rat vas deferens. Fed. Proc. 32:795, 1973.

Lee TJF, Westfall DP, Smith DJ and Fleming WW: Morphological evidence for an increase in cell contacts (nexus) between smooth muscle cells of the rat vas deferens after postganglionic denervation. Pharmacologist, 15:172, 1973.

Lee TJF, Su C and Bevan JA: Neurogenic vasoconstriction of the rabbit basilar artery. Winter Conference on Brain Research, Steamboat Springs, Colorado, 1975.

Lee TJF, Su C and Bevan JA: Dilator innervation of the cat cerebral arteries. Fed. Proc. 34:796, 1975.

Lee TJF, Su C and Bevan JA: Atypical adrenergic and nonadrenergic innervation of cerebral arteries of cat and rabbit. Sixth International Congress on Pharmacology, Helsinki, 1975.

Lee TJF: Sympathetic vasoconstrictor and nonsympathetic vasodilator innervation of cerebral arteries. Second International Symposium on Vascular Neuroeffector Mechanism, University of Odense, Denmark, 1975.

Lee TJF: Sympathetic innervation of rabbit basilar artery: Neuromuscular relationship. Fed. Proc. 36:1036, 1977.

Lee TJF: Vasoconstrictor and dilator innervation in cat and rabbit cerebral arteries. First International Symposium on Neurogenic Control of the Brain Circulation, Stockholm, June, 1977. Lee TJF and Chiueh CC: Sympathetic adrenergic nerve in rabbit cerebral artery. Fed. Proc. 37:792, 1978.

Lee TJF: Is norepinephrine (NE) the constrictor transmitter in the rabbit basilar artery? 7th International Congress on Pharmacology, Paris, 1978.

Lee TJF: Possible involvement of a second transmitter in neurogenic vasoconstriction of the rabbit ear artery. Pharmacologist, 21:201, 1979.

Lee TJF, Araki H and Su C: Tyramine-induced constriction in cerebral blood vessels. Fed. Proc. 29:582, 1980.

Lee TJF: Agranular vesicle-containing vasodilator nerves in cerebral blood vessels. Pharmacologist, 22:282, 1980.

Lee TJF: Sympathetic vasoconstrictor nerve in the rabbit vasilar artery. Presented at 1st Illinois Heart Association Cardiovascular Club, Champaign, IL, 1980.

Lee TJF: Morphopharmacological study of cerebral vasoconstrictor and dilator nerves. Presented at Symposium on Cerebral Blood Flow: Effect of Nerves and Neurotransmitters, Iowa City, Iowa, June 16-18, 1981.

Lee TJF: Is acetylcholine the dilator transmitter in cerebral blood vessels: A critical examination. Presented at Tenth International Symposium on Brain Circulation and Metabolism, St. Louis, June 18-24, 1981.

Lee TJF: Cerebral vasodilator and constrictor nerves. Presented at Symposium on Cerebral Blood Flow: Effect of Nerves and Neurotransmitters, Iowa City, Iowa, June, 1981.

Lee TJF: Innervation and transmitters in control of blood vessel tone. Presented in form of round-table discussion at Midwestern Pharmacology Society Meeting, Chicago, June 3-5, 1981. Lee TJF: Acetylcholine: A vasoconstrictor or dilator transmitter in cerebral artery? Eighth International Congress on Pharmacology, Tokyo, Japan, 1981.

Lee TJF: Nerve-muscle relationships in cerebral artery. Fourth International Symposium on Vascular Neuroeffector Systems, Kyoto, Japan, 1981.

Lee, TJF and Sarwinski S: Transmitter role of norepinephrine and acetylcholine in pig cerebral arteries. Fed. Proc., 41:1233, 1982.

Saito A and Lee TJF: Adrenergic innervation of the brain arteries in spontaneously hypertensive rat. Fed. Proc., 41:1649, 1982.

Saito A and Lee TJF: The innervation of the brain arteries in chronic renal hypertensive rats. Fed.

Proc. 42:649, 1983.

Saito A and Lee TJF: Autonomic innervation of the brain arteries in renal hypertensive rats. Presented at 11th International Symposium on Cerebral Blood Flow and Metabolism, Paris, France, June, 1983.

Linnik MD and Lee TJF: Electrical stimulation-induced cerebral vasodilation is not mediated by acetylcholine. Pharmacologist 25:269, 1983.

Saito A and Lee TJF: Innervation of the rabbit anterior communicating artery. Pharmacologist 25:139, 1983.

Lee TJF, Saito A and Beresin I: Vasoactive intestinal polypeptide, but not substance P or acetylcholine is the potential cerebral vasodilator transmitter. Presented at 1983 Society of Neuroscience Meeting, Boston, MA.

Lee TJF, McIlhany M and Sarwinski S: Hemolysate enhances neurogenic vasoconstriction of isolated cerebral arteries. Fed. Proc. 43:836, 1984.

Saito A, Wu JY and Lee TJF: Cholinergic lnnervation of cerebral arteries: Immunohistochemical demonstration using antibodies against cholineacetyltransferase. Fed. Proc. 43:304, 1984.

Saito A and Lee TJF: PHI (PHI-27)-immunoreactive nerves in cerebral arteries. 9th Intl. Congress of Pharmacology, London, 1984.

Lee TJF, McIlhany MP, Saito A and Sarwinski S: The effect of erythrocyte extracts on cerebral blood vessel tone. 9th Intl. Congress of Pharmacology, London, 1984.

Linnik MD and Lee TJF: Hemoglobin (HMG) alters TNS-induced responses of perfused pig cerebral arteries, but not 3H-norepinephrine (NE) release. Fed. Proc. 44:1588, 1985.

Wang JY and Lee TJF: Differential distribution of adrenergic receptors in pig cerebral arteries (CA's). Fed. Proc. 44:1008, 1985.

Saito A, Goto K, Masaki T and Lee TJF: Uptake of serotonin into sympathetic nerves of cerebral arteries. Jap. J. Pharmacol. 35, 1985.

Saito A, Goto K, Masaki T and Lee TJF: Distribution and effect of vasoactive intestinal polypeptide in brain arteries. Blood Vessels 8:6, 1985 (in Japanese).

Lee TJF and Saito A: Altered cerebral vessel innervation in spontaneously hypertensive and renal hypertensive rats. 5th International Symposium on SHR and Related Studies, Kyoto, Japan, 1985. Lee TJF: Cholinergic vasodilator mechanism in cerebral arteries. Symposium on Recent Advances in Pharmacology, Taipei, Taiwan, 1985.

Shirasaki Y, Su C, Lee TJF, Cline WH Jr. and Nickols GA: Enhanced vascular relaxation to nitrovasodilators with endothelial removal in DOCA-salt hypertensive rats. FASEB, 1986.

Su C, Shirasak Y, Lee TJF, Cline WH Jr. and Nickols GA: Effects of aging and hypertension on endothelium regulated vascular responses. FASEB, 1986.

Linnik MD and Lee TJF: Effect of hemoglobin on the uptake of [3H]norepinephrine and

[3H]choline chloride into porcine cerebral arteries. FASEB, 1986.

Tsuji T, Su C and Lee TJF: Presynaptic beta2-adrenoceptor-mediated facilitation of pressor responses in prehypertensive SHR. FASEB, 1986.

Tsuji T and Lee TJF: Effect of uptake blockers on pressor responses in prehypertensive rat. ASPET 1986.

Shirasaki Y, Nickols GA and Lee TJF: Endothelium-regulated vascular responses in hypertension. Springfield Blood Vessel Symposium: Neurohumoral Control of Blood Vessel Tone, Springfield, IL, 1986.

Tsuji T and Lee TJF: Enhanced presynaptic beta-2 adrenoceptor-mediated modulation of the pressor response in prehypertensive SHR. Springfield Blood Vessel Symposium: Neurohumoral Control of Blood Vessel Tone, Springfield, IL, 1986.

Linnik MD and Lee TJF: Effect of hemoglobin on neurogenic parameters in porcine cerebral

arteries. Springfield Blood Vessel Symposium: Neurohumoral Control of Blood Vessel Tone, Springfield, IL, 1986.

Imai H, Wu JY and Lee TJF: Cholinergic innervation in cerebral arteries of normotensive and hypertensive rats. Soc. Neuroscience, 1986.

Yu JG, Wu JY and Lee TJF: Cholinergic innervation in cerebral blood vessels. Soc. Neuroscience, 1986.

Tsuji T and Lee TJF: Effects of neuronal uptake inhibitor on the pressor responses in the prehypertensive SHR. Pharmacologist, 28:154, 1986.

Miao FJP and Lee TJF: Bilirubin potentiates norepinephrine-induced constriction in cerebral arteries.

Fed. Proc., 46:643, 1987.

Tsuji T and Lee TJF: Presynaptic beta adrenoceptors facilitate pressor responses in prehypertensive rats. Fed. Proc., 1987.

Tsuji T and Lee TJF: Beta-adrenoceptor-mediated facilitation of the pressor responses in young SHR. Jap. J. Pharmacol. 43:291P, 1987.

Saito A, Masaki T, Lee TJF and Goto K: Calcitonin gene-related peptide (cGRP)-containing nerves in large cerebral arteries of cats: Effect of capsaicin. Jap. J. Pharmacol. 43:97P, 1987.

Nishimura M., Su C and Lee TJF: Characteristics of neurogenic vasodilation in the rat hindquarters. Jap. J. Pharmacol. 43:99P, 1987.

Miao FJP and Lee TJF: Effects of bilirubin on cerebral neurogenic and endothelium-mediated vasodilation. Pharmacologist, 29:125, 1987.

Shirasaki Y, Nickols GA and Lee TJF: Endothelial modulation of vascular tone in hypertension. Blood Vessels, 24:222, 1987.

Lee TJF, Shiraskai Y, Shillcutt SD and Sarwinski S: Is vasoactive intestinal polypeptide the vasodilator transmitter in cerebral arteries? Soc. Neuroscience 13:65, 1987.

Miao FJP and Lee TJF: Bilirubin and cerebral vessel tone. Eastern Student Research Forum, 1987. Lee TJF, Saito A and Shillicutt S: Serotonin is an alternative vasoconductor in rabbit cerebral arteries. International Congress of Pharmacology, Sidney, Australia, 1987.

Sunagane N and Lee TJF: Vasomotor responses of cerebral vein in the pig. 61st General Meeting of Japanese Pharmacology Society, Fukuoka, Japan, 1988.

Sunagane N and Lee TJF: Serotonin-induced relaxations and constrictions of porcine pial veins in vitro. FASEB, J. 2:A721, 1988.

Saito A, et al: Calcitonin gene-related peptide and cerebral vascular tone. 61st Japanese Pharmacology Soc. Meeting, March, Fukuoka, Japan, 1988.

Lee TJF: Serotonin-containing fibers in cerebral blood vessels. International Symposium on Biosignalling in Cardiac and Vascular Systems. September, 1988, Kyoto, Japan.

Lee TJF: Endothelial regulation of vascular responses in hypertension. International Symposium on Biosignalling in Cardiac and Vascular Systems. September, 1988, Kyoto, Japan.

Lee TJF: Cerebral vessel innervation in health and diseases. International Symposium on Biopeptide in Cardiovascular System. Fuzhou, China, July, 1988.

Sunagane N and Lee TJFLee TJF and Sarwinski S: Neurogenic vasodilation in cerebral arteries is associated with enhanced cyclic GMP contents, FASEB J., 1989.

Miao FJP, Sarwinski S and Lee TJF: Enhanced norepinephrine-induced vasoconstrictions in hyperbilirubinemic Gunn rats, FASEB J., 3(4):A1023, 1989.

Lee TJF, Imai H, Wu JY and Okuno T: GABAergic innervation in brain arteries, XVI international symposium on cerebral blood flow and metabolism, Bologna, Italy, May 28-June 1, 1989.

Miao FJF and Lee TJF: Cholinergic and VIPergic innervations in cerebral arteries of the cat.

Symposium on Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June, 1989.

Okuno T and Lee TJF: Morphological relationship between GABAergic and other autonomic innervations in brain arteries. Symposium on Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June, 1989.

Saito A, Mima T, Shingeno T, Lee TJF and Toto K: Role of calcitonin generelated peptide (CGRP) as a vasodilator transmitter in large cerebral arteries of cats. Symposium on Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June, 1989.

Lee TJF and Sunagane N: 5-HT1-like receptors mediate pial venous relaxation. Symposium on Neurotransmission and Cerebrovascular Function. Symposium on Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June, 1989.

Imai H, Itakura T, Komai N, Lee TJF, Okuno T and Wu JY: Immunohistochemical evidence for the presence of GABAergic nerves in cerebral blood vessels. Symposium on Neurotransmission and Cerebrovascular Function, LaNapoule, French Riviera, June, 1989.

Lee TJF, Fang YX and Nickols GA: Cyclic nucleotides and cerebral vasodilation. Symposium on neurotransmission and cerebrovascular function. LaNapoule, French Riviera, June, 1989.

Lee TJF, Miao FJP, Okuno T and Kawashima K: Acetylcholine-immunoreactive fibers in cerebral and peripheral blood vessels, Soc. Neurosci, 15(1):407, 1989.

Okuno T and Lee TJF: GABAergic innervation in cerebral arteries, Soc. Neurosci, 15(1):837, 1989. Miao FJP and Lee TJF: VIP- and ChAT-immunoreactive fibers are distinctive fibers in cerebral arteries of the cat, Soc. Neurosci., 15(1):837, 1989.

Miao FJP and Lee TJF: Single- and double-labeling immunocytochemistry: Cholinergic and VIPergic innervations in cerebral arteries. Eastern Student Research Forum, xx, 1990.

Miao FJP and Lee TJF: ACh and VIP: Coupling mechanism and postsynaptic interactions in cerebral arteries. Eastern Student Research Forum, xx, 1990.

Miao FJP and Lee TJF: Endogenous and exogenous bilirubin: Effects on vasomotor tone. Eastern Student Research Forum, xx, 1990.

Maio FJP and Lee TJF: Homologous tachyphylaxis in cerebral and peripheral blood vessels. FASEB J, 1990.

Maio FJP and Lee TJF: Postsynaptic interactions between cholinergic & VIP-ergic nerves in cerebral arteries. National Student Research Forum, xx, 1990.

Okuno T, Lee TJF, Imai H, Hakura T, Ueno M, Naka Y, Nakai K, Hayashi S and Komai K: GABAergic innervation in cerebral arteries: A morphological and pharmacological study. Soc. Neuroscience, St. Louis, 16(1):523, 1990.

Lee TJF, Fang YX, Nickols MA and Nickols GA: Cerebral neurogenic vasodilation is predominantly mediated by enhanced cyclic GMP content. Eur. J. Pharmacol,183(3):805, 1990. Miao FJF and Lee TJF: Vascular homologous tachyphylaxis. Eur. J. Pharmacol, 183:2217, 1990. Lee TJF, Fang YX and Nickols GA: Miltiple transmitters are involved in cerebral neurogenic vasodilation. 7th Vascular Neuroeffector Mechanism Symposium. Blood Vessels, 1990.

Miao FJP and Lee TJF: Postsynaptic interactions between ACh and VIP in cerebral arteries. 7th Vascular Neuroeffector Mechanism Symposium. Blood Vessels, 1990.

Lee TJF: Neurogenic control of cerebral vascular tone. Am. Physiol. Soc. - Chinese Physiol. Soc. Joint Meeting, Taipei, Tiawan, November, 1990.

Lee TJF: Neurogenic vasodilator mechanism in cerebral blood vessels. Keio J. Med. 39:270, 1990. Lee TJF and Miao FJP: VIPergic and cholinergic interactions in cerebral arteries. Symposium on neuropeptide receptors and related antagonists. Shainghai, China, November, 1990.

Ueno M and Lee TJF: 5HT1 receptors mediate inhibition of spontaneous rhythmic contraction of porcine pial veins. Brain '91, June, 1991.

Lee TJF, Sarwinski S and Chen FY: Cerebral neurogenic vasodilation is mediated by nitric oxide

or its related substance. Brain '91, June, 1991.

Lee TJF, Sarwinski S and McIlhany M: A major component of cerebral neurogenic vasodilation is mediated by nitric oxide. FASEB J., 5:A740, 1991.

Ueno M and Lee TJF: 5HT1 receptor-mediated inhibition of porcine pial venous tone. Soc. Neuroscience, 17(part 1):1174, 1991.

Okuno T, Iatakura T, Nakai K, Komai N, Ueno M and Lee TJF: Adventitial ganglion cell-like structures in the major cerebral arteries of the cat: an immunohistochemical study. Soc. Neurosciences 17(part 1):542, 1991.

Ueno M and Lee TJF: Serotonin inhibition of porcine pial venous tone is mediated by cAMP synthesis. FASEB J. 6:A1169, 1992.

Asada Y and Lee TJF: Role of myoendothelial junctions in endothelium-dependent vasodilation. FASEB J. 6:A974, 1992.

Chen FY and Lee TJF: Role of nitric oxide in cerebral neurogenic vasodilation. FASEB J. 6:A1462, 1992.

Lee TJF and Sarwinski S: NO, VIP and CGRP in cerebral neurogenic vasodilation. FASEB 1993. Lee TJF, Chen FY and Sarwinski S: Role of NO, VIP and CGRP in cerebral neurogenic vasodilation. Brain 1993, Sendai, Japan.

Lee TJF: Nitric oxide in cerebral neurogenic vasodilation. International Symposium on Cerebral Blood Vessels. Zao, Japan, June 1993.

Chen X, Chen FY and Lee TJF: Ginsenosides induce a NO-mediated relaxation of the corpus cavernosum of the rabbit. FASEB 1993.

Chen FY and Lee TJF: Nitric oxide as a dilator transmitter in cerebrovasculature. Midwest-America Chinese Science and Technology Conference, June 1993, St. Louis.

Sun MH and Lee TJF: Dopamine constricts porcine pial veins. ASPET, San Francisco, 1993.

Chen FY and Lee TJF: Conversion of citrulline to arginine in cerebral perivascular nerves. Experimental Biology 1994.

Chen X, Hu YC, Scholkano BA and Lee TJF: Ramipril (R) reverses oxidized LDL-induced inhibition of vasodilation and attenuates atherogenesis in cholesterol-fed rabbits. Experimental Biology 1994.

Chen X, Hu YC, Scholken BA and Lee TJF: Protection of ramiprilat on oxidized LDL-impaired endothelium-dependent relaxation in rabbit aorta. XIIth International Congress of Pharmacology, Montreal, Canada, July, 1994.

Chen FY and Lee TJF: Role of NO in cerebral neurogenic vasodilation. XIIth International Congress of Pharmacology, Montreal, Canada, July, 1994.

Chen X, Hu YE, Scholken BA and Lee TJF: Ramipril effects on atherosclerosis and oxidized LDL-induced dysfunction of aortic endothelium in rabbits. The Second International Symposium on cGRP and symposium on peptides and their antagonists, Montreal, Canada, July 31-August 5, 1994.

Ishine T and Lee TJF: ?2-adrenoceptors mediate NE blockade of 5HT inhibition of SRC in porcine pial veins. Exp. Biol., 1995.

Lee TJF, Sarwinski S and Chen FY: L-citrulline reverses nitro-L-arginine (NLA)-induced inhibition of cerebral neurogenic vasodilation. Exp. Biol., 1995.

Ishine T and Lee TJF: Spontaneous rhythmic constrictions in porcine pial veins: Effects of serotonin and norepinephrine. Brain 1995.

Lee TJF, Chen FY and Sarwinski S: Role of citrulline-arginine cycle in cerebral neurogenic vasodilation. Brain 1995.

Yu JG and Lee TJF: Citrulline conversion to arginine is mediated by argininosuccinate pathway. Exp. Biol., 1996.

Lee TJF: Ginseng, aphrodisiac and NO. International Symposium on Traditional Chinese Medicine. Taipei, Taiwan, April, 1996.

Kimura T, Yu JG and Lee TJF: Colocalization of choline acetyltransferase and nitric oxide synthase in cerebral arteries and sphenopalatine ganglia of the cat and pig. Soc. Neuroscience, 22 (part 2):1566, 1996.

Lee TJF: Endothelial regulation of cerebral vascular tone. 7th International Headache Research Seminar, Copenhagen, Denmark, November 22-24, 1996.

Satoh E, Nishimura M and Lee TJF: Comparison of ability to release norepinephrine from four portions of porcine cerebral arteries. Jap J Pharmacol 73 (suppl 1): 268P, 1997.

Lee TJF: Nitric oxide and cerebrovascular function. 44th Annual Meeting of Japanese Society of Anesthesiology, Niigata, Japan, April, 1997.

Okuno T, Kohama A, Itakura T and Lee TJF: Nitric oxidergic innervation in cerebral pial arteries of the cat: an ultrastructural evidence of co-localization with VIP in nerve terminals. J Cereb Blood Flow Metab 17(Suppl. 1): S407, 1997.

Lee TJF, Yu JG, O'Brien WE, Kimura T and Ishine T: L-citrulline conversion to L-arginine in porcine cerebral arteries and veins. J. Cereb. Blood Flow Metab. 17(Suppl. 1): S347, 1997.

Zhang W, Edvinsson L and Lee TJF: Nicotine-induced relaxation in the porcine basilar artery is blocked by guanethidine. Symposium on Mechanisms of Cerebrovascular Function and Regulation (Williamsburg, VA), p. 66, 1997.

Liu J and Lee TJF: Prejunctional muscarinic receptors mediate inhibition of nitrix oxide release in porcine basilar arteries. Symp. on Mechanisms of Cerebrovascular Function and Regulation (Williamsburg, VA), p. 50, 1997.

Liu J and Lee TJF: Mechanism of presynaptic muscarinic modulation of nitric oxide-mediated cerebral neurogenic vasodilation. Experimental Biology 1998.

Zhang W, Edvinsson L and Lee TJF: Nicotine-nduced NO-mediated cerebral neurogenic vasodilation is dependent on intact adrenergic innervation. IUPHAR, Munchen, Germany, 1998. Lee TJF: Nitric oxide, anesthetics, and cerebrovascular function. 10th Asian-Australian Congress of Anesthesiologists. Taipei, Taiwan, June 10-14, 1998.

Lee TJF, Yu JG, O'Brien WE, Kimura T and Ishine T: Conversion of L-citrulline to L-arginine in porcine cerebral blood vessels. Postcongress Symposium on Biology of nitric oxide, Graz, Austria, July, 1998.

Yu JG, Chang XF and Lee TJF: Segregation of cerebral vascular VIPergic-nitric oxidergic and cholinergic-nitric oxidergic innervation in the pig. Soc Neurosci 24:110, 1998.

Ishine T, Bouchelet I, Hamel E and Lee TJF: 5-HT7 receptors mediate porcine pial venous relaxation. Experimental Biology Meeting, 1999.

Liu J, Evans SM and Lee TJF. N-type Ca2+channels in Cultured Rat Sphenopalatine Ganglion Neurons: an Electrophysiological and Morphological Study. Exp Biol Meeting, 1999.

Zhang W, Edvinsson L and Lee TJF: Presynaptic adrenergic modulation of NO-mediated cerebral neurogenic vasodilation. Brain 99, Copenhagen, June, 1999.

Ishine T, Yu JG, Asada Y and Lee TJF: Nitric oxide is the predominant mediator for neurogenic vasodilator in porcine pial veins. Brain 99, Copenhagen, June, 1999.

Ishine T, Bouchelet I, Hamel E and Lee TJF: Serotonin 5-HT7 Receptors mediate relaxation of porcine pial veins. Brain 99, Copenhagen, June, 1999.

Liu J, Evans SM and Lee TJF: Presynaptic M2-receptors mediate inhibition of N-type Ca2+ channels in cerebral perivascular NOergic nerves. Society of Neuroscience 25: 1504, 1999. Lee TJF, Liu J and Evans MS: Presynaptic modulation of NO-mediated cerebral neurogenic vasodilation. (8th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists), Nov, 1999 (abstract).

Mishra R, Khardori N and Lee TJF: Cerebrovascular tone regulation in septic shock: Role of NF-

kappa B-dependent L-citrulline mediated relaxation. SIU School of Medicine symposium, 1999.

Mishra R and Lee TJF: L-citrulline-mediated porcine basilar artery relaxation following endotoxin treatment. Presented at ASPET meeting, June 2000, Boston.

Yamamoto R, Asada Y, Kobayashi H, Shiraishi S, Wada A and Lee TJF: Nitric oxide generated by NOS-1 increases exocytotic norepinephrine release. Jap J Pharmacol 82 (suppl 1): 224p, 2000.

Mishra R and Lee TJF: L-citrulline-mediated porcine basilar artery relaxation following endotoxin treatment. Exp Biol Meeting, 2000.

Yamamoto R, Asada Y, Kobayashi H, Wada A and Lee TJF: Neuronal nitric oxide increases exocytotic norepinephrine release. ISHR, Chicago, 2000.

Lee TJF, Liu J and Evans SM: Cholinergic-nitrergic vasodilator innervation in cerebral arteries. 3rd TBA symposium, Society of Neuroscience, New Orleans, Nov 4, 2000.

Murphy LL and Lee TJF: Aphrodisiac effect of ginsenosides in experimental animals. 3rd TBA symposium, Society of Neuroscience, New Orleans, Nov 4, 2000.

Chen YC, Mishra R, Yang LL and Lee TJF: Oroxylin A inhibits iNOS expression in porcine cerebral arteries. Brain01, June 9-13-2001, Taipei, Taiwan.

Si ML and Lee TJF: ?7-nicotinic acetylcholine receptors on adrenergic nerves mediate nicotine-induced NOergic neurogenic vasodilation in the pig cerebral arteries. Brain01, June 9-13-2001, Taipei, Taiwan.

Mishra R, Wang DJ, Ramkumar V and Lee TJF: Vasomodulatory effects of hyperosmotic agents on porcine cerebral arteries. Brain01, June 9-13-2001, Taipei, Taiwan.

Mishra R, Chiu WT and Lee TJF: Mechanisms of nitric oxide (NO) production in porcine cerebral arteries following endotoxin treatment. Brain01, June 9-13-2001, Taipei, Taiwan.

Wang CC, Lu J, Yang LL and Lee TJF: Cantharidin Enhanced NO-mediated Cerebral Vasodilation in Adult Pigs. Brain01, June 9-13-2001, Taipei, Taiwan.

Lee TJF. Presynaptic modulation of nitrergic neurogenic vasodilation in cerebral arteries. Japanese J Pharmacology 85 (sppl 1) 17p, 2001.

Lee TJF: Modulation of NOergic transmission by classic transmitters in large cerebral arteries. Symposium on Brain Activation and CBF Control. June 6-8, 2001, Tokyo, Japan.

Si ML and Lee TJF: ?7-nAChRs on sympathetic nerves mediate nicotine-induced nitrergic neurogenic vasodilatioin in the pig basilar arteries. Soc Neurosc November 2001.

Si ML and Lee TJF: Choline induces nitrergic neurogenic vasodilation in porcine basilar arteries. IUPHAR 2002, San Francisco, Calif.

Lefler SR and Lee YJF: A NEW TOTAL SYNTHESIS OF OROXYLIN A. ACS Rocky Mountain Regional Meeting. October 12 -15, 2002

Jadhav V and Lee TJF: PGE2 constricts porcine large cerebral arteries. Experimental Biology, April 2003

Si M and Lee TJF: Pb2+ inhibition of sympathetic ?7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. Experimental Biology, April 2003

Lee TJF: axoaxonal interaction in regulation of cerebral vascular tone. Joint meeting of

Pharmacology and Physiology, Fukuoka, Japan, March, 2003

Lee TJF: Autonomic modulation of cerebral neurogenic nitrergic vasodilation. Presented at

International Symposium Vascular Smooth Muscle (organizer, T Sunano), Osaka, Japan, May 2003 Long C, Si ML, Sarwinski S, Evans MS and Lee TJF: Imipramine, desipramine and fluoxetine inhibit choline-induced, ?7-nAChR-mediated cerebral nitrergic vasodilation. Accepted for presentation at Society of Neuroscience meeting 2003.

Jabre A, Jadhav V, Lee TJF: The “tissue bath“, an in vitro technique to study vasospasm in the animal model. AANS, April, 2004

Tseng TL (曾子玲), Chen MF (陳美芳), Kuo JS (郭重雄), Chen CP (陳清漂), Lee TJF (李哲夫): Oroxylin A Prevention of LPS-induced Cardiovascular Dysfunction. Tzu Chi University annual research conference, May, 2004

Kuo FH, Lin CJ, Tseng TL, Lee TJF, Tseng YL: GC-MS analysis and quantification of oroxylin A in human urine following administration of the extract of Huang Qin. The 19th JACBS, Taipei, Taiwan, p350, 2004

Jadhav V and Lee TJF: Role of endogenous prostaglandin E2 in modulation of autonomic neurotransmission in cerebral arteries. 34th Society of Neuroscience, 2004

Mozayan M, Si ML, Chen MF, and Lee TJF: ChEIs block sympathetic α7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. 34th Society of Neuroscience, 2004

Si ML, Long C, Yang DI, Chen MF, and Lee TJF: ?-Amyloid inhibition of sympathetic a7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries was prevented by statins. 34th Society of Neuroscience, 2004

Vikram Jadhav, Anthony Jabre, and Tony Jer-Fu Lee: PGE2 regulation of cerebral vascular tone. Joint Annual Biomedical Meeting, Taipei, March, 2005

M.H. Kung, P.Y. Chen, M.F. Chen, A.C. Lua, Tony J.F. Lee: Amphetamine and MDMA inhibit sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilation in porcine basilar arteries. Joint Annual Biomedical Meeting, Taipei, March, 2005

S.Y. Lai, P.Y. Chen, M.F. Chen, Tony J.F. Lee: Ketamine inhibition of sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilation in porcine cerebral arteries. Joint Annual Biomedical Meeting, Taipei, March, 2005

Yi-Ching Liu, Su-Yu Lai, Ming-Hsing Kung, Po-Yi Chen, Mei-Fang Chen, Tony J-F Lee: Nicotine-inducedcerebral nitrergic vasodilation in Taiwanese pigs. Annual Biomedical Meeting, Taipei, March, 2005

T.L. Tseng, Y.L. Tseng, C.P. Chen, M.F. Chen, J.S. Kuo, Tony J-F Lee: Oroxylin A prevention of LPS-induced cardiovascular dysfunction. Annual Biomedical Meeting, Taipei, March, 2005

CH Liu, C-T Lin, TJF Lee, and YL Tseng: Detection of flavonoids in huang qin extract by gas chromatography-mass spectrometry. Annual Biomedical Meeting, Taipei, March, 2005

Po-Yi Chen, Mei-Fang Chen, M Mozayan, and Tony Jer-Fu Lee: Protein kinase C (PKC) regulation of ?7-nAChRs. Joint Annual Biomedical Meeting, Taipei, March, 2006

Suling Huang, Cheng Long, Hsiao-Ching Hsu, I-Chen Lin, Mei-Fang Chen, and Tony JF Lee: Fluoxetine blocks α7-nAChR-mediated cerebral nitrergic neurogenic vasodilation.

Joint Annual Biomedical Meeting, Taipei, March, 2006

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