Dear Hiring Manager:

Please consider the enclosed resume as my application for the Applied Value LLC Intern, and I am available from this June to September. I am currently a graduate student in the Electrical Engineering Program at Columbia University, where I have acquired valuable skills of solving challenge problems in creative ways. Now I am eager to start at this position, where I can put into practice the skills gained through academic and professional experiences. Meanwhile, I have done technology analysis and support intern before, I believe I could afford this intern, plus my technical academic background.

Now my major is focusing on integrated circuits and systems. I have already

splendidly completed mini-projects of my academic track in this semester such as Microprocessor design, RTL design, and Computer architecture design. Meanwhile, I also have a great interest and confidence in computer science and software

development including hardware design language, System C and Java. This semester I am doing projects with these languages. All of these projects and language

programming requires for analytical work and algorithm design with high-level math skills.

Furthermore, my bachelor research is control theory and operation research. I believe that those kinds of knowledge render me sensitive and ease to do procedure

optimization of manufactory. Meanwhile, experiencing with the training by grand companies, such as Shanghai Baosteel factory, Shanghai Volkswagen, I gain acquaint with basic rules of applying knowledge into practical world as well as getting along with other colleagues.

I'm a hardworking and responsible person always looking to better myself and

working in a precise manner. I have always been playing the role of the team leader in the school, and I quite understand the importance of collaborating with my team members. I'm sure if I’m given an interview opportunity, I will be able to tell you more details about my achievements and aspirations. I appreciate your consideration of this application, and I look forward to hearing from you.

Sincerely,

Tianchen Li

 

第二篇：cover letter 模板

Dear Editor,

We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am

Sincerely yours,

case2

Dear Editor,

We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.

We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.

Sincerely yours,

Case 3 Sample Cover Letter[the example used is the IJEB]

Dear Editor of the [please type in journal title or acronym]:

Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses

to your submission requirements.

1. Title and the central theme of the article.

Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])

3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?

The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed network. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].

4. Names, addresses, and email addresses of four expert referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail:

Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.

Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail: [email=jadams@au.edu.au]jadams@au.edu.au%20

Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18, pp. 88-98.

Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail:

Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.

Relationship: Former professor, dissertation chairman.

Mr. Frank Young

Partner, ABC Consulting

888, Seashore Highway

Won Kok, Kowloon

Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886

e-mail: [email=fyoung@abcc.com]fyoung@abcc.com%20

Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.

Relationship: I have worked with Mr. Young in several consulting projects in the past three years.

Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.

Sincerely,

Johnny Smith

之一:被metabolic engineering接受

Dear chief editor

Enclosed please find the manuscript, which titled “题目l ”, authored by 作者.

In order to increase the yield and productivity of desired metabolites, most current metabolic engineering have focused on manipulating enzyme level through the amplification, addition, or deletion of a particular pathway. In deed, cofactors, such as NADH/NAD+, CoA, ATP, vitamin and metal, play a central role in biochemical reactions and the production of different fermentation products. It is conceivable that cofactor levels

and the availability of the required form of the cofactor can become limiting in cofactor-dependent production systems. Therefore, the manipulation of these cofactor levels may be crucial to further increase production.

This manuscript choose the metabolism of pyruvate in Torulopsis glabrata, an industrial microbiology, as a model system, to demonstrate that manipulation of vitamin and metal levels as a novel tool to regulate the central carbon metabolic pathway and redistribute the carbon flux. In this study, the carbon flux was blocked at the key node of pyruvate, and the pyruvate pool size was 68.7 g/L. The valve of carbon flux could open selectively through increasing vitamin and calcium level from pyruvate pool and then -ketoglutarate. By combination of high vitamin?redistribute it to synthesize and calcium, the pyruvate pool size was decrease to 21.8 g/L, but the -ketoglutarate pool was increase to 43.7 g/L. The success of manipulation? -ketoglutarate without any genetic modification?metabolic flux from pyruvate to demonstrates that the manipulation of vitamin level may provides a novel tool to realize metabolic engineering goals.

Considering that manipulation vitamin and metal levels to redistribute carbon flux in industrial microbiology has never been reported, and the topic of cofactor level and the carbon flux distribution is an interesting topic for Metabolic Engineering readers, we would be very happy if the submitted manuscript could be reviewed and considered for publication on Metabolic Engineering.

We are looking forward to hearing from you.

Sincerely yours,

之二: 被biotechnology and bioengineering接受

Dear Chief editor

Enclosed please find the manuscript entitled “题目”, authored by 作者.

Product inhibition is a universal phenomenon for the production of organic acid fermentation. The mechanism of production inhibition involve in the low pH and the toxicity of organic acid. However, it is conceivable that the osmotic press caused by pH buffer agent is responsible for product inhibition. Therefore, enhancement the osmotic-resistance of strain may be crucial to further increase organic acid production. This manuscript chose the production of pyruvate in Torulopsis glabrata as a model system to demonstrate the enhancement of osmotic-resistance as a novel tool to further increase pyruvate production. In this study, the yield of cell growth and pyruvate production deceased with increasing of osmotic press (sodium chlorate and sorbitol). Pyruvate production by the mutant strain RS23, which selected after pH-control continuous culture which utilized 70 g/L NaCl as selective pressure, reached 94.3 g/L at 82 h (yield on glucose of 0.635 g/g) in a 7-l fermentator with 150 g/L glucose as carbon source. The possibility of enhancing pyruvate production by increasing osmotic pressure may provide an alternative approach to enhance metabolites production in yeast.

Considering product inhibition caused by high osmotic pressure and increase the

tolerance of NaCl could enhance organic acid production in industrial microbiology has never been reported, and the topic of the mechanism of product inhibition and the alleviation of product inhibition is an interesting topic for Biotechnology and Bioengineering readers, we would be very happy if the submitted manuscript could be reviewed and considered for publication on Biotechnology and Bioengineering.

We are looking forward to hearing from you.

之三:被journal of biotechnology所接受

Enclosed please find the manuscript, which titled "题目", authored by作者.

In order to increase the production and productivity of desired metabolites, most current metabolic engineering have focused on manipulating enzyme level through the amplification, addition, or deletion of a particular pathway. In deed, cofactors, such as NADH/NAD+, ATP and vitamin, play a central role in biochemical reactions. It is conceivable that cofactor levels and the availability of the required form of the cofactor can become limiting in cofactor-dependent production systems. Therefore, the manipulation of these cofactor levels may be crucial to further increase production.

In order to increase the productivity of pyruvate in T. glabrata, in this study, we examined two approaches to increase the availability of intracellular NAD+, that is, to supplement nicotinic acid, or to increase the activity of a biologically active NADH-dependent alcohol dehydrogenase (ADH) and to add electron acceptor to oxidize the excessive NADH at lower DO concentration. With increasing the availability of NAD+ under low dissolved oxygen concentration, high glycolytic flux, high pyruvate concentration, high pyruvate yield on glucose, and high pyruvate productivity, in combination with an increase activities of key enzymes in glycolytic pathway were observed. This manuscript demonstrated that, for the first time, enhancing the availability of NAD+ through increasing the activity of ADH and adding acetaldehyde as exterior electron acceptor could increase the glycolytic flux and the metabolites productivity.

Considering that the relationship between cofactor level (engineering) and the metabolite productivity has never been reported in eukaryotic cell, and the topic of cofactors and carbon metabolism is an interesting topic for Journal of Biotechnology reader. We would be very happy if the submitted manuscript could be reviewed and considered for publication on Journal of Biotechnology.

sci论文投稿的cover letter 模板

Dear Prof. XXXXX, Here within enclosed is our paper for consideration to be published on "(Journal name)". The further information about the paper is in the following: The Title: XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX The Authors: XXXXX XXXXX and XXXXX The authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere. I am the corresponding author and my address

and other information is as follows, Address: Department of XXXXXXXXX, Tsinghua University, Beijing, 10084, P.R.China E-mail: XXXXX@mail. Tel: 86-10-62785001 Fax: 86-10-62785001 Thank you very much for consideration! Sincerely Yours, Dr. XXXXXXXXXXX

Dear XX (Editor): Here is our paper submitted to "(XX Journal)". The Title: XXXX The Authors: XXX XXX and XXX In this paper, we ... The authors claim that none of the material in the paper has been published or is under consideration for publication

elsewhere. The corresponding author is Dr. XXX and his address and other information is as following: Address: Department of XXX, XX University, ..., P.R.China E-mail: XXXXX@ Tel: +86-xxx-xxxxxxxx Fax: +86-xxx-xxxxxxxx Thank you very much for consideration!

Sincerely Yours,

Dr. xxx

（1） Dear Mr. ** 1. The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed. 2. I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience. kind regards. Your sincerely, 通讯作者

（2） Dear Dr. 主编name: We submit our manuscript entitled " 文章title" to 杂志名for publication. 接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。 All authors have seen the manuscript and approved to submit to your journal. Thank you very much for your attention and consideration. Sincerely yours, 通讯作者 （3） Dear Dr. 主编name: We submit our manuscript entitled "文章title" to 杂志名for publication. 接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。 All authors have seen the manuscript and approved to submit to your journal. Thank you very much for your attention and consideration.

Sincerely yours,

通讯作者 （4）Dr. *** Editor-in-Chief, *** (add address) January 22, 2003 Dear Dr. **, Enclosed herewith please find 3 copies of a MS by: ?***. *** and ***? entitled:

“**********”, which we would like to submit for publication in the ?******'. Looking forward to your decision, With kind personal regards, Sincerely yours, （5） Dear Prof. Gil: This is a manuscript by ** and ** entitled “.......”. It is submitted to be considered for publication as a “...” in your journal. This paper is new. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe the paper may be of particular interest to the readers of your journal as it ........ Correspondence should be addressed to ** at the following address, phone and fax number, and email address: ... Thanks very much for your attention to our paper. Sincerely yours, **